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Maria Diakonova: Recent Advances in Prolactin Research

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Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis.In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.

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Donna Florino Alaimo,L. Juane Heflin: Students with Autism Spectrum Disorders : Effective Instructional Practices

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Broadened public awareness of autism and other associated spectrum disorders, combined with continuing research, means that more students than ever before are being identified with these conditions. This book is an excellent resource for any teacher working with students who have ASD because it discusses how to identify and describe individuals with autism spectrum disorder, develop effective programs, create contexts for instruction, accommodate sensory issues, use applied behavior analytic instructional strategies and program for challenging behavior. Separate chapters are devoted to communication, socialization, academic skill acquisition and non-academic environments. Information on the use of technology is infused throughout the book and makes this an invaluable reference for educators.

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Cake baking made easy Step-by-Step Cakes is the perfect book to have to hand when you're mastering the art of cake baking. Over 130 recipes are made easy with simple instructions and photography helping you every step of the way. Master the art of sponges, cheesecakes, tarts and meringue cakes with 35 classic cake recipes plus exciting variations for when you're feeling more adventurous. Excellent value, Step-by-Step Cakes will help you bake all the world's favourite cake recipes every time. All content previously published in Step-by-Step Baking.

Encompassing quilts, ceramics, letterpress books, wallpaper, and textiles, and moving from well-known museums to home workshops and political protests, Extra/Ordinary is an eclectic introduction to the "craft culture" referenced and celebrated by artists promoting new ways of thinking about the role of craft in contemporary art. Contributors. Elissa Auther, Anthea Black, Betty Bright, Nicole Burisch, Maria Elena Buszek, Jo Dahn, M. Anna Fariello, Betsy Greer, Andrew Jackson, Janis Jefferies, Louise Mazanti, Paula Owen, Karin E. Peterson, Lacey Jane Roberts, Kirsty Robertson, Dennis Stevens, Margaret Wertheim America was both a uniquely powerful global force: a force that was forward-looking, the focus of hope, money and ideas, and at the same time elusive, unpredictable and in fundamental respects unwilling to confront these unwished for responsibilities. Tooze shows how the fate of effectively Guitar Chords for Beginners: A Beginners Guitar Chord Book with Open Chords and More download ebook the whole of civilization - the British Empire, the future of peace in Europe, the survival of the Weimar Republic, both the Russian and Chinese revolutions and stability in the Pacific - now came to revolve around this new power's fraught relationship with a shockingly changed world. The Deluge is both a brilliantly illuminating exploration of the past and an essential history for the present.

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Stella Cubison: Organic Fruit Production and Viticulture

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Fruit production is one of the most challenging areas of organic growing, and those wanting to grow fruit organically have often found it difficult to obtain the necessary technical information. Essential reading for serious gardeners, smallholders, small-scale organic growers and farmers wishing to diversify their crop range, this book covers the organic cultivation of all of the most popular pome and stone fruits, strawberries, cane and bush fruits. A separate wide-ranging chapter, written by Roy Cook, is provided on the important subject of viticulture.

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Eric Clapton: Eric Clapton: The Autobiography

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Eric Clapton is far more than a rock star. Like Dylan and McCartney he is an icon and a living legend. He has sold tens of millions of records, played sell-out concerts all over the world and been central to the significant musical developments of his era. His guitar playing has seen him hailed as 'God'. Now for the first time, Eric tells the story of his personal and professional journeys in this pungent, witty and painfully honest autobiography. These are the memoirs of a survivor, someone who has reached the pinnacle of success, who has had it all, but whose demons have never left him. Eric tells his story as it is, hiding nothing, with a directness and searing honesty that will make this book one of the most compelling memoirs of our time.

This six-volume series traces the history of imperial China from the beginnings of unification under the Qin emperor in the third century BCE Eric Clapton: The Autobiography free pdf to the end of the Qing dynasty in the early twentieth century. Each book covers a broad range of topics at a concise length and is grounded in the latest scholarship. This is an essential series for everyone interested in Chinese history and culture. The Tang dynasty is often called China's 'golden age', a period of commercial, religious, and cultural connections from Korea and Japan to the Persian Gulf, and a time of unsurpassed literary creativity. Mark Lewis captures a dynamic era in which the empire reached its greatest geographical extent under Chinese rule, painting and ceramic arts flourished, women played a major role both as rulers and in the economy, and China produced its finest lyric poets in Wang Wei, Li Bo, and Du Fu. The Chinese engaged in extensive trade on sea and land. Merchants from Inner Asia settled in the capital, while Chinese entrepreneurs set off for the wider world, the beginning of a global diaspora.

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Richelle Mead: Thorn Queen

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Eugenie Markham is a shaman for hire, paid to bind and banish creatures from the Otherworld. But after her last battle, she's also become queen of the Thorn Land. It's hardly an envious life, not with her kingdom in tatters, her love life in chaos, and Eugenie eager to avoid the prophecy about her firstborn destroying mankind. And now young girls are disappearing from the Otherworld, and no one - except Eugenie - seems willing to find out why. Eugenie has spilled plenty of fey blood in her time, but this enemy is shrewd, subtle, and nursing a very personal grudge. And the men in her life aren't making things any easier. Her boyfriend Kiyo is preoccupied with his pregnant ex, and sexy fey king Dorian always poses a dangerous distraction. With or without their help, Eugenie must venture deep into the Otherworld and trust in an unpredictable power she can barely control. Reluctant queen or not, Eugenie has sworn to do her duty - even if it means facing the darkest - and deadliest - side of her nature...

Book study groups and professional learning communities, click here to save 15% when you order 15 copies of Teaching for Comprehending and Fluency, K-8. "Teaching for Comprehending and Fluency, K-8" is the next new breakthrough from Irene Fountas and Gay Su Pinnell. Offering a complete picture of how to skillfully teach meaning making and fluency within any instructional context, "Teaching for Comprehending and Fluency, K-8," supports you with frameworks for high-quality instruction that describe appropriate expectations for comprehending, fluency, and vocabulary development. Fountas and Pinnell's teaching and assessment frames will give you a firm understanding of your students' reading levels: where they are, where they should be, and what they need to do to get there-for any reader, in any grade, at any moment. You'll also gain insight about the specific demands that fiction and nonfiction texts place on readers and about how effective readers think "within" a text, "beyond" a text, and "about" a text to gain rich understandings. As you learn about how the characteristics of texts help or hinder a reader's improvement, you'll find effective teaching strategies for: comprehending, word solving, fluency, and vocabulary writing about reading in a variety of genres and using writing as a tool for thinking using guided reading with fiction and nonfiction books discussing books during interactive read-aloud and literature study taking part in shared and performance reading. Fountas and Pinnell's teaching tips, smart strategies, proven classroom ideas, and professional-learning opportunities will lead the way as you discover how to help readers develop effective systems of strategic actions over time. You'll also learn how to take running records of reading behavior to assess comprehension and fluency then use those assessments to inform and differentiate your teaching. In addition, Fountas and Pinnell have also added a dynamic companion resource to "Teaching for Comprehending and Fluency, K-8": a DVD containing short, focused video segments that illustrate concepts from the book and demonstrate exemplar teaching in real classroom settings. The DVD is also a repository of useful materials to support your work-including blackline masters, forms, checklists, and numerous other classroom tools. Fountas and Pinnell have developed detailed teaching guides for "Teaching for Thorn Queen download PDF Comprehending and Fluency." Perfect for staff development leaders or teacher educators, these guides offer all the specifics on leading a professional development program or preservice course on comphrension instruction with "Teaching for Comprehending and Fluency" as the core text. Each of the guides is written to address a specific course of study and is available for free download along with its accompanying course syllabus: Professional Development Program:

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Timothy Garton Ash: The File: a Personal History

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"Eloquent, aware and scrupulous . . . a rich and instructive examination of the Cold War past." --The New York Times In 1978 a romantic young Englishman took up residence in Berlin to see what that divided city could teach him about tyranny and freedom. Fifteen years later Timothy Garton Ash--who was by then famous for his reportage of the downfall of communism in Central Europe--returned. This time he had come to look at a file that bore the code-name "Romeo." The file had been compiled by the Stasi, the East German secret police, with the assistance of dozens of informers. And it contained a meticulous record of Garton Ash's earlier life in Berlin. In this memoir, Garton Ash describes what it was like to rediscover his younger self through the eyes of the Stasi, and then to go on to confront those who actually informed against him to the secret police. Moving from document to remembrance, from the offices of British intelligence to the living rooms of retired Stasi officers, The File is a personal narrative as gripping, as disquieting, and as morally provocative as any fiction by George Orwell or Graham Greene. And it is all true. "In this painstaking, powerful unmasking of evil, the wretched face of tyranny is revealed." --Philadelphia Inquirer

Take a journey around the world to discover the homes of children just like you! Where in the world do children live in reed houses on floating islands? Where are the highest homes: in the city skyscrapers, or in the snowy mountains? Why are some houses in India painted blue, and why do some people in South Africa paint patterns on their homes? Find out in The File: a Personal History download epub Homes Around the World! Children will love reading about the homes of their contemporaries in other countries; from underground homes and floating homes, to eco-homes, and the most unusual homes. Includes Art Station activities where readers are encouraged to use their new knowledge creatively! Readers can discover all the foul facts about WICKED WORDS, including how to be very rude ...without anybody knowing, some murky Medieval jokes and what to say if someone calls you mundungus, hackum or Jabbernowl. With a bold, accessible new look and a heap of extra-horrible bits, these bestselling titles are sure to be a huge hit with yet another generation of Terry Deary fans.

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Stefan Ball: Bloom: Using Flower Essences for Personal Development and Spiritual Growth

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Insightful and engaging, "Bloom" explains how to use the Bach Flower Remedies for personal and spiritual growth. Written by a key team member at the Dr Edward Bach Centre, "Bloom" reveals how the Bach flower essences offer a complete system that can help us to change our lives for the better. Chapters 1-7 explore the ways in which the remedies relate to different life experiences, as well as intriguing schools of religious and philosophical belief. Interspersed with chapters 1-7, chapters i-vii look closely at the individual remedies in the system, explaining when to take each one and what they will do for you. Containing a wealth of personal stories, individual testimonies and fascinating anecdotes, "Bloom" has something to offer to anyone interested in the Bach Flower Remedies or drawn to personal development in general. Discover how to use the remedies to improve your own life, and to grow into your full potential.

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Mark Charan Newton: The Broken Isles: Legends of the Red Sun: Book Four

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War spills into the Boreal Archipelago, as two rival cultures bring their eternal battle into this adjacent realm. Fresh from a military victory, Commander Brynd Lathraea plans to rebuild the city of Villiren, where he is confronted with a dilemma. There are friendly forces who have no other choice but to live alongside his own people, and their numbers will be required to fight in the looming conflict. The commander turns politician as he seeks to build bridges and embrace mysterious new technologies to further his ambitions. However, many in Villiren are sceptical of aliens coming to their city, tensions run high, and even the dream of a peaceful future brings with it inevitable clashes of beliefs. Meanwhile, Villjamur has been destroyed. A vast swathe of refugees from the legendary city are now on the run from an immense alien presence in the sky. Villages are being cleared and people are dying en masse. And Inquisitor Fulcrom finds himself at the helm of an operation to aid the refugee exodus to the coast, but it's a race against time before this threatened genocide is complete. Ancient civilisations line up on the field of battle. Exotic creatures and a possible god walk alongside citizens of the Empire. As the Legends of the Red Sun series draws to a close, there will be one final and immense conflict to decide the fate of multiple cultures forever.

ALONEThirteen-year-old Brian Robeson is on his way to visit his father when the single-engine plane in which he is flying crashes. Suddenly, Brian finds himself alone in the Canadian wilderness with nothing but a tattered Windbreaker and the hatchet his mother gave him as a present -- and the The Broken Isles: Legends of the Red Sun: Book Four pdf dreadful secret that has been tearing him apart since his parent's divorce. But now Brian has no time for anger, self pity, or despair -- it will take all his know-how and determination, and more courage than he knew he possessed, to survive.For twenty years Gary Paulsen's award-winning contemporary classic has been the survival story with which all others are compared. This new edition, with a reading group guide, will introduce a new generation of readers to this page-turning, heart-stopping adventure.

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